This manifesto in twenty-two theses is a chapter of the book Knowledges Born in The Struggle (2019), edited by the Portuguese sociologist, Boaventura de Sousa Santos. In this manifesto-like text Boaventura de Sousa Santos states his ideas about the intertwined nature of domination systems in our world and the possibilities to confront them. Sarazad has translated this text in a collective endeavour.